Toxic And Anti-Cancerogenic Effect Of Brown Seaweed Cystoseira Tamariscifolia
نویسنده
چکیده
Cystoseira tamariscifolia is a brown alga which represents an important natural biomass on the Moroccan Atlantic coast. Study of the acute toxicity of this species was carried out on Swiss albinos mice. The LD50 was determined through the Spearman-Karber method by injecting the aqueous algal extract to 36 mice organized in lots of 6 animals each for 6 concentrations and the experiments were conducted in triplicates. A dose of 0.5ml of each concentration of the aqueous extract were injected to the mice intraperitonally while the 0.5 ml of saline at 0.9% was injected to the control lot. The anticancerogenic effect study was carried out on murin myelom cells P3/X63-Ag8.653, using different concentrations of the aqueous extract of the alga. The results obtained show a toxic effect of the alga on the mices with LD50 of 738.61±34 μg of alga/ g of body weight. A significant anticancerogenic effect of the extract was also detected on myelom cells; it is propotionnel to the used concentrations.
منابع مشابه
Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds.
Marine organisms are a prolific source of drug leads in a variety of therapeutic areas. In the last few years, biomedical, pharmaceutical and nutraceutical industries have shown growing interest in novel compounds from marine organisms, including macroalgae. Cystoseira is a genus of Phaeophyceae (Fucales) macroalgae known to contain bioactive compounds. Organic extracts (hexane, diethyl ether, ...
متن کاملSeasonal biochemical and photophysiological responses in the intertidal macroalga Cystoseira tamariscifolia (Ochrophyta).
Seasonal changes in the biochemistry and photophysiology of the brown macroalga Cystoseira tamariscifolia was analyzed in southern Spain. Total carbon and nitrogen contents, phenolic compounds, antioxidant and photosynthetic activities were seasonally determined over two years. Carbon, nitrogen and photoprotective phenolic contents were higher in winter and spring than in summer and autumn. Ant...
متن کاملAnti-oxidant, Anti-inflammatory and Anti-proliferative Effects of Aqueous Extracts of Three Mediterranean Brown Seaweeds of the Genus Cystoseira
Seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. Despite the diversity in quality and quantity of the Mediterranean Tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...
متن کاملAnti-oxidant, Anti-inflammatory and Anti-proliferative Effects of Aqueous Extracts of Three Mediterranean Brown Seaweeds of the Genus Cystoseira
Seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. Despite the diversity in quality and quantity of the Mediterranean Tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...
متن کاملPhlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
Purified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus), were characterized by HPLC-DAD-ESI-MSn. Fucophloroethol, fucodiphloroethol, fucotriphloroethol, 7-phloroeckol, phlorofucofuroeckol and bieckol/dieckol were identified. The ant...
متن کامل